In vitro testing of novel aminoglycosides antibiotics, and resistance mechanism of Bdellovibrio bacteriovorus
Once new lead compounds and antimicrobials have been developed through discovery and synthetic approaches, an initial selection process will be performed followed by extensive antimicrobial testing in vitro and ex vivo. The most promising antimicrobial drug candidates will thereafter also be tested in appropriate animal models. To this end, the research of ESR 4.1 will build on one of the largest strain collections of MDR bacteria in Europe, which is available within the Department of Medical Microbiology at the University Medical Center Groningen (UMCG).
Department: Medical Microbiology, UMCG, GSMS
Principal investigator(s): Alexander Friedrich, Jan Maarten van Dijl
Publications
Cavallo, F. M., Jordana, L., Friedrich, A. W., Glasner, C., & van Dijl, J. M. (2021). Bdellovibrio bacteriovorus: a potential ‘living antibiotic’ to control bacterial pathogens. Critical Reviews in Microbiology, 47(5), 630-646. https://doi.org/10.1080/1040841X.2021.1908956
da Cruz Campos, A. C., Cavallo, F. M., Andrade, N. L., van Dijl, J. M., Couto, N., Zrimec, J., Lo Ten Foe, J. R., Rosa, A. C. P., Damasco, P. V., Friedrich, A. W., Chlebowicz-Flissikowska, M. A., & Rossen, J. W. A. (2019). Determining the Virulence Properties of Escherichia coli ST131 Containing Bacteriocin-Encoding Plasmids Using Short- and Long-Read Sequencing and Comparing Them with Those of Other E. coli Lineages. Microorganisms, 7(11), 534. https://www.mdpi.com/2076-2607/7/11/534