Nanomedicine based approaches to antibiotic resistance
Nanosized materials are processed by cells in different ways than small molecules, such as standard drugs, opening up the possibility of using them as drug delivery vehicles in nanomedicine. Encapsulating antibiotics in nanosized carriers could improve their delivery, thus also reducing the occurrence of antibiotic resistance. In this research project, targeted carriers of different design will be developed in collaboration with the Laboratories of Prof. Wolfgang Parak (Marburg University, Germany) and Prof. Francesco Stellacci (EPFL, Switzerland). This will also include strategies to reduce clearance by the immune system. Their behavior on cells and bacterial cultures will be tested with cell biology approaches, using a combination of methods such as flow cytometry and fluorescence imaging in order to track their uptake and efficacy.
Department: Groningen Research Institute of Pharmacy, RUG
Principal investigator(s): Anna Salvati
Raineri, E. J. M., Yedavally, H., Salvati, A., & van Dijl, J. M. (2020). Time-resolved analysis of Staphylococcus aureus invading the endothelial barrier. Virulence, 11(1), 1623-1639. https://doi.org/10.1080/21505594.2020.1844418
Leinardi, R., Pavan, C., Yedavally, H., Tomatis, M., Salvati, A., & Turci, F. (2020). Cytotoxicity of fractured quartz on THP-1 human macrophages: role of the membranolytic activity of quartz and phagolysosome destabilization. Archives of Toxicology, 94(9), 2981-2995. https://doi.org/10.1007/s00204-020-02819-x
Palma Medina, L. M., Becker, A.-K., Michalik, S., Yedavally, H., Raineri, E. J. M., Hildebrandt, P., Gesell Salazar, M., Surmann, K., Pförtner, H., Mekonnen, S. A., Salvati, A., Kaderali, L., van Dijl, J. M., & Völker, U. (2019). Metabolic Cross-talk Between Human Bronchial Epithelial Cells and Internalized Staphylococcus aureus as a Driver for Infection*. Molecular & Cellular Proteomics, 18(5), 892-908. https://doi.org/10.1074/mcp.RA118.001138