Antibacterial silica-silver nanocomposites for clinical applications
The aim of this research project is to develop antimicrobial silica-silver nanocomposites for clinical applications. During the Alert Program, quaternary ammonium-containing copolymers (pQA) are anchored on the surface of silica nanoparticles (SiNPs). Subsequent addition of AgNO3 induces in situ formation of AgBr nanoparticles in the polymer shell. The formed SiNPs-pQA/AgBr nanocomposites are then incorporated into a number of matrix resins customized for different clinical applications. These silica-silver nanocomposites will be extensively evaluated, in vitro and in vivo, in their physical, mechanical, biological, microbiological and aesthetic properties to meet the demands for clinical use such as dental restorative materials, bone-graft substitutes and/or coating materials for medical devices and implants. Furthermore, 3D printability of these nanocomposites will be explored in order to fabricate personalized 3D printed dental and medical devices while maintaining their antibacterial property.
Department: Biomedical Engineering, UMCG
Principal investigator(s): Yijin Ren
Publications
Wu, Y., Li, C., van der Mei, H. C., Busscher, H. J., & Ren, Y. (2021). Carbon Quantum Dots Derived from Different Carbon Sources for Antibacterial Applications. Antibiotics, 10(6), 623. https://www.mdpi.com/2079-6382/10/6/623
Wu, Y., Wei, H., van der Mei, H. C., de Vries, J., Busscher, H. J., & Ren, Y. (2021). Inheritance of physico-chemical properties and ROS generation by carbon quantum dots derived from pyrolytically carbonized bacterial sources. Materials Today Bio, 12, 100151. https://doi.org/https://doi.org/10.1016/j.mtbio.2021.100151
Wu, Y., van der Mei, H. C., Busscher, H. J., & Ren, Y. (2020). Enhanced bacterial killing by vancomycin in staphylococcal biofilms disrupted by novel, DMMA-modified carbon dots depends on EPS production. Colloids and Surfaces B: Biointerfaces, 193, 111114. https://doi.org/https://doi.org/10.1016/j.colsurfb.2020.111114